A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure

Medland, S. E., Zayats, T., Glaser, B., Nyholt, D.R., Gordon, S. D., Wright, M. J., Montgomery, G. W., Campbell, M. J., Henders, A. K., Timpson, N. J., Peltonen, L., Wolke, D., Ring, S. M., Deloukas, P., Martin, N. G., Smith, G. D., & Evans, D. M. (2010) A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure. American Journal of Human Genetics, 86(4), pp. 519-525.

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Abstract

The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 2D:4D, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 2D:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.

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ID Code: 91977
Item Type: Journal Article
Refereed: No
Additional Information: Medland, Sarah E
Zayats, Tetyana
Glaser, Beate
Nyholt, Dale R
Gordon, Scott D
Wright, Margaret J
Montgomery, Grant W
Campbell, Megan J
Henders, Anjali K
Timpson, Nicholas J
Peltonen, Leena
Wolke, Dieter
Ring, Susan M
Deloukas, Panos
Martin, Nicholas G
Smith, George Davey
Evans, David M
eng
90600705/Medical Research Council/United Kingdom
G0600705/Medical Research Council/United Kingdom
G0800582/Medical Research Council/United Kingdom
G9815508/Medical Research Council/United Kingdom
Wellcome Trust/United Kingdom
Research Support, Non-U.S. Gov't
2010/03/23 06:00
Am J Hum Genet. 2010 Apr 9;86(4):519-25. doi: 10.1016/j.ajhg.2010.02.017. Epub 2010 Mar 18.
Keywords: Adolescent, Anthropometry, *Biological Markers, Child, Cohort Studies, Female, Fingers/*anatomy & histology, Genetic Variation, Genotype, Humans, Longitudinal Studies, Male, Meta-Analysis as Topic, Pregnancy, Prenatal Exposure Delayed Effects/*genetics, RNA-Binding Proteins/*genetics, Testosterone/*physiology, Twin Studies as Topic
DOI: 10.1016/j.ajhg.2010.02.017
ISSN: 0002-9297
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 American Ssociety of Human Genetics
Copyright Statement: Creative Commons 3.0 Unported
Deposited On: 18 Jan 2016 00:50
Last Modified: 15 Feb 2016 22:35

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