The shared genetics of migraine and anxious depression

Ligthart, Lannie, Nyholt, Dale R., Penninx, Brenda W.J.H., & Boomsma, Dorret I. (2010) The shared genetics of migraine and anxious depression. Headache, 50(10), pp. 1549-60.

View at publisher

Abstract

OBJECTIVES

To investigate:

  • (1) whether shared genetic factors influence migraine and anxious depression;

  • (2) whether the genetic architecture of migraine depends on anxious depression;

  • (3) whether the association between migraine and anxious depression is causal.

BACKGROUND

Migraine and anxious depression frequently occur together, but little is known about the mechanisms causing this association.

METHODS

A twin study was conducted to model the genetic architecture of migraine and anxious depression and the covariance between them. Anxious depression was also added to the model as a moderator variable to examine whether anxious depression affects the genetic architecture of migraine. Causal models were explored with the co-twin control method.

RESULTS

Modest but significant phenotypic (rP=0.28), genetic (rG=0.30), and nonshared environmental (rE=0.26) correlations were found between the 2 traits. Interestingly, the heritability of migraine depended on the level of anxious depression: the higher the anxious depression score, the lower the relative contribution of genetic factors to the individual differences in migraine susceptibility. The observed risk patterns in discordant twins are most consistent with a bidirectional causal relationship.

CONCLUSIONS

These findings confirm the genetic association between migraine and anxious depression and are consistent with a syndromic association between the 2 traits. This highlights the importance of taking comorbidity into account in genetic studies of migraine, especially in the context of selection for large-scale genotyping efforts. Genetic studies may be most effective when migraine with and without comorbid anxious depression are treated as separate phenotypes.

Impact and interest:

24 citations in Scopus
Search Google Scholar™
25 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 91980
Item Type: Journal Article
Refereed: Yes
Keywords: Adolescent, Adult, Aged, Aged, 80 and over, Anxiety/*genetics, Depressive Disorder/*genetics, Female, Humans, Male, Middle Aged, Migraine Disorders/*genetics, Models, Genetic, Netherlands, Odds Ratio, Questionnaires, Risk Factors, Twins, Dizygotic, Twins, Monozygotic, Young Adult
DOI: 10.1111/j.1526-4610.2010.01705.x
ISSN: 1526-4610
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 18 Jan 2016 23:23
Last Modified: 12 Feb 2016 03:00

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page