Common variants in the trichohyalin gene are associated with straight hair in Europeans

Medland, S. E., Nyholt, D.R., Painter, J. N., McEvoy, B. P., McRae, A. F., Zhu, G., Gordon, S. D., Ferreira, M. A., Wright, M. J., Henders, A. K., Campbell, M. J., Duffy, D. L., Hansell, N. K., Macgregor, S., Slutske, W. S., Heath, A. C., Montgomery, G. W., & Martin, N. G. (2009) Common variants in the trichohyalin gene are associated with straight hair in Europeans. American Journal of Human Genetics, 85(5), pp. 750-5.

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Abstract

Hair morphology is highly differentiated between populations and among people of European ancestry. Whereas hair morphology in East Asian populations has been studied extensively, relatively little is known about the genetics of this trait in Europeans. We performed a genome-wide association scan for hair morphology (straight, wavy, curly) in three Australian samples of European descent. All three samples showed evidence of association implicating the Trichohyalin gene (TCHH), which is expressed in the developing inner root sheath of the hair follicle, and explaining approximately 6% of variance (p=1.5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations.

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ID Code: 92000
Item Type: Journal Article
Refereed: Yes
Additional Information: Medland, Sarah E
Nyholt, Dale R
Painter, Jodie N
McEvoy, Brian P
McRae, Allan F
Zhu, Gu
Gordon, Scott D
Ferreira, Manuel A R
Wright, Margaret J
Henders, Anjali K
Campbell, Megan J
Duffy, David L
Hansell, Narelle K
Macgregor, Stuart
Slutske, Wendy S
Heath, Andrew C
Montgomery, Grant W
Martin, Nicholas G
eng
AA07535/AA/NIAAA NIH HHS/
AA10248/AA/NIAAA NIH HHS/
AA13320/AA/NIAAA NIH HHS/
AA13321/AA/NIAAA NIH HHS/
AA13326/AA/NIAAA NIH HHS/
AA14041/AA/NIAAA NIH HHS/
MH66206/MH/NIMH NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
2009/11/10 06:00
Am J Hum Genet. 2009 Nov;85(5):750-5. doi: 10.1016/j.ajhg.2009.10.009. Epub 2009 Nov 5.
Keywords: Adolescent, Adult, Alleles, Amino Acid Sequence, Amino Acid Substitution, Australia/ethnology, Child, Chromosomes, Human, Pair 1, Cohort Studies, European Continental Ancestry Group/*genetics, Female, Gene Frequency, Genetic Markers, *Genetic Variation, Genetics, Population, Genome, Human, Genome-Wide Association Study, Genotype, Geography, Hair/*anatomy & histology, Hair Follicle/anatomy & histology, Haplotypes, Humans, Intermediate Filament Proteins, Karyotyping, Linkage Disequilibrium, Male, Meta-Analysis as Topic, Methionine/metabolism, Molecular Sequence Data, Nuclear Family, Polymorphism, Single Nucleotide, Protein Precursors/*genetics, Young Adult
DOI: 10.1016/j.ajhg.2009.10.009
ISSN: 0002-9297
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 by The American Society of Human Genetics.
Deposited On: 19 Jan 2016 02:21
Last Modified: 20 Jan 2016 01:04

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