Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
Benyamin, B., Ferreira, M. A., Willemsen, G., Gordon, S., Middelberg, R. P., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, M. J., Wallace, L., Frazer, I. H., Heath, A. C., de Geus, E. J., Nyholt, D.R., Visscher, P. M., Penninx, B. W., Boomsma, D. I., Martin, N. G., Montgomery, G. W., & Whitfield, J. B. (2009) Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nature Genetics, 41(11), pp. 1173-5.
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10(-20)), transferrin saturation (combined P = 2.2 x 10(-23)) and erythrocyte mean cell volume (MCV, combined P = 1.1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Benyamin, Beben
Ferreira, Manuel A R
Middelberg, Rita P S
McEvoy, Brian P
Henders, Anjali K
Campbell, Megan J
Frazer, Ian H
Heath, Andrew C
de Geus, Eco J C
Nyholt, Dale R
Visscher, Peter M
Penninx, Brenda W
Boomsma, Dorret I
Martin, Nicholas G
Montgomery, Grant W
Whitfield, John B
AA014041/AA/NIAAA NIH HHS/
AA07535/AA/NIAAA NIH HHS/
AA10248/AA/NIAAA NIH HHS/
MH081802/MH/NIMH NIH HHS/
R01 AA007535/AA/NIAAA NIH HHS/
R01 AA007535-08/AA/NIAAA NIH HHS/
R01 AA010249/AA/NIAAA NIH HHS/
R01 AA010249-04/AA/NIAAA NIH HHS/
R01 AA014041-01A1/AA/NIAAA NIH HHS/
R01 MH059160/MH/NIMH NIH HHS/
R01 MH059160-04/MH/NIMH NIH HHS/
R01 MH081802/MH/NIMH NIH HHS/
R01 MH081802-01/MH/NIMH NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Nat Genet. 2009 Nov;41(11):1173-5. doi: 10.1038/ng.456. Epub 2009 Oct 11.
|Keywords:||Chromosomes, Human, Pair 22, *Erythrocyte Volume, Erythrocytes/*cytology/*metabolism, Genome-Wide Association Study, *Homeostasis, Humans, Iron/*blood, Membrane Proteins/*genetics, *Polymorphism, Single Nucleotide, Serine Endopeptidases/*genetics, Transferrin/metabolism|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2009 Nature America Inc.|
|Deposited On:||19 Jan 2016 02:26|
|Last Modified:||20 Jan 2016 05:44|
Repository Staff Only: item control page