Anti-bacterial surfaces: Natural agents, mechanisms of action, and plasma surface modification

Bazaka, K., Jacob, M.V., Chrzanowski, W., & Ostrikov, K. (2015) Anti-bacterial surfaces: Natural agents, mechanisms of action, and plasma surface modification. RSC Advances, 5(60), pp. 48739-48759.

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Strategies that confine antibacterial and/or antifouling property to the surface of the implant, by modifying the surface chemistry and morphology or by encapsulating the material in an antibiotic-loaded coating, are most promising as they do not alter bulk integrity of the material. Among them, plasma-assisted modification and catechol chemistry stand out for their ability to modify a wide range of substrates. By controlling processing parameters, plasma environment can be used for surface nano structuring, chemical activation, and deposition of biologically active and passive coatings. Catechol chemistry can be used for material-independent, highly-controlled surface immobilisation of active molecules and fabrication of biodegradable drug-loaded hydrogel coatings. In this article, we comprehensively review the role plasma-assisted processing and catechol chemistry can play in combating bacterial colonisation on medically relevant coatings, and how these strategies can be coupled with the use of natural antimicrobial agents to produce synthetic antibiotic-free antibacterial surfaces.

Impact and interest:

28 citations in Scopus
26 citations in Web of Science®
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ID Code: 92055
Item Type: Journal Article
Refereed: Yes
Keywords: Plasma polymerization, Plasma medicine
DOI: 10.1039/C4RA17244B
ISSN: 2046-2069
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 20 Jan 2016 05:28
Last Modified: 20 Jan 2016 20:48

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