Polymer encapsulation of magnesium to control biodegradability and biocompatibility

Bazaka, Kateryna, Ketheesan, Natkunam, & Jacob, Mohan V. (2014) Polymer encapsulation of magnesium to control biodegradability and biocompatibility. Journal of Nanoscience and Nanotechnology, 14, pp. 8087-8093.

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Clinical utility of biodegradable magnesium implants is undermined by the untimely degradation of these materials in vivo. Their high corrosion rate leads to loss of mechanical integrity, peri–implant alkalization and localised accumulation of hydrogen gas. Biodegradable coatings were produced on pure magnesium using RF plasma polymerisation. A monoterpene alcohol with known anti-inflammatory and antibacterial properties was used as a polymer precursor. The addition of the polymeric layer was found to reduce the degradation rate of magnesium in simulated body fluid. The in vitro studies indicated good cytocompatibility of non-adherent THP–1 cells and mouse macrophage cells with the polymer, and the polymer coated sample. The viability of THP–1 cells was significantly improved when in contact with polymer encapsulated magnesium compared to unmodified samples. Collectively, these results suggest plasma enhanced polymer encapsulation of magnesium as a suitable method to control degradation kinetics of this biomaterial.

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4 citations in Scopus
4 citations in Web of Science®
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ID Code: 92058
Item Type: Journal Article
Refereed: Yes
Keywords: magnesium, implantable materials, biocompatibility, encapsulation
DOI: 10.1166/jnn.2014.9409
ISSN: 1533-4899
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 20 Jan 2016 05:10
Last Modified: 21 Jan 2016 00:45

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