Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Bazaka, Kateryna, Jacob, Mohan V., Crawford, Russell J., & Ivanova, Elena P. (2012) Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms. Applied Microbiology and Biotechnology, 95(2), pp. 299-311.

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Abstract

Biomaterials play a fundamental role in disease management and the improvement of health care. In recent years, there has been a significant growth in the diversity, function, and number of biomaterials used worldwide. Yet, attachment of pathogenic microorganisms onto biomaterial surfaces remains a significant challenge that substantially undermines their clinical applicability, limiting the advancement of these systems. The emergence and escalating pervasiveness of antibiotic-resistant bacterial strains makes the management of biomaterial-associated nosocomial infections increasingly difficult. The conventional post-operative treatment of implant-caused infections using systemic antibiotics is often marginally effective, further accelerating the extent of antimicrobial resistance. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore sought. The surface modification of biomaterials has the potential to alleviate pathogenic biofouling, therefore preventing the need for conventional antibiotics to be applied.

Impact and interest:

34 citations in Scopus
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49 citations in Web of Science®

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ID Code: 92069
Item Type: Journal Article
Refereed: Yes
Keywords: biomaterials, surface treatment, biofilm, bacterial attachment
DOI: 10.1007/s00253-012-4144-7
ISSN: 0175-7598
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 20 Jan 2016 03:40
Last Modified: 21 Jan 2016 04:08

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