Pro-apoptotic NOXA is implicated in atmospheric-pressure plasma-induced melanoma cell death
Ishaq, Musarat, Bazaka, Kateryna, & Ostrikov, Kostya (2015) Pro-apoptotic NOXA is implicated in atmospheric-pressure plasma-induced melanoma cell death. Journal of Physics D: Applied Physics, 48(46), p. 464002.
Atmospheric-pressure plasma (APP) has been successfully used to treat several types of cancers in vivo and in vitro, with the effect being primarily attributed to the generation of reactive oxygen species (ROS). However, the mechanisms by which APP induces apoptosis in cancer cells require further elucidation. In this study, the effects of APP on the expression of 500 genes in melanoma Mel007 cancer cells were examined. Pro-apoptotic phorbol-12-myristate-13-acetate-induced protein (PMAIP1), also known as NOXA, was highly expressed as a result of APP treatment in a dose-dependent manner. Blocking of ROS using scavenger NAC or silencing of NOXA gene by RNA interference inhibited the APP-induced NOXA genes upregulation and impaired caspases 3/7 mediated apoptosis, confirming the important role plasma-generated ROS species and pro-apoptotic NOXA play in APP-induced cancer cell death.
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|Item Type:||Journal Article|
|Keywords:||atmospheric pressure plasma, melanoma, apoptosis|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2015 IOP Publishing Ltd|
|Deposited On:||20 Jan 2016 22:47|
|Last Modified:||21 Jan 2016 21:35|
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