Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample
Zhao, Zhen Zhen, Nyholt, Dale R., Le, Lien, Thomas, Shane, Engwerda, Christian, Randall, Louise, Treloar, Susan A., & Montgomery, Grant W. (2007) Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample. Human Reproduction, 22(9), pp. 2389-2397.
Tumour necrosis factor (TNF) is a pleiotropic cytokine with a wide range of immunoregulatory effects. Variation in the promoter region of TNF and the neighbouring lymphotoxin alpha (LTA) gene might be associated with endometriosis.
We examined the association between endometriosis and common single-nucleotide polymorphisms (SNPs) or haplotypes in the TNF/LTA region in an Australian sample by analysing 26 SNPs in 958 endometriosis cases and 959 unrelated controls. We selected functional SNPs in the coding and the promoter region of the TNF gene and HapMap tagging SNPs and typed them on a Sequenom MassARRAY platform. A key SNP (rs1800630) in the promoter region typed in previous studies did not give reliable results. Therefore, we also examined a statistically identical (r(2) = 1) SNP (siSNP) (rs2844482), identified using the web based program ssSNPer.
Genotype completion rate was 99.5% for SNPs spanning a region of 15.5 kb across the TNF/LTA locus. There was no evidence for association between endometriosis and TNF/LTA SNPs or SNP haplotypes in our case-control study.
Our data suggest both TNF and LTA genes are not major susceptibility genes for endometriosis.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Australia, Base Sequence, Endometriosis/*genetics, Female, Gene Frequency, Humans, Lymphotoxin-alpha/*genetics, *Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Tumor Necrosis Factor-alpha/*genetics|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2007 The Authors|
|Deposited On:||27 Jan 2016 22:48|
|Last Modified:||09 Feb 2016 01:02|
Repository Staff Only: item control page