Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities

Nyholt, D. R., Gillespie, N. G., Heath, A. C., Merikangas, K. R., Duffy, D. L., & Martin, N. G. (2004) Latent class and genetic analysis does not support migraine with aura and migraine without aura as separate entities. Genetic Epidemiology, 26(3), pp. 231-244.

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Abstract

Latent class and genetic analyses were used to identify subgroups of migraine sufferers in a community sample of 6,265 Australian twins (55% female) aged 25-36 who had completed an interview based on International Headache Society (IHS) criteria. Consistent with prevalence rates from other population-based studies, 703 (20%) female and 250 (9%) male twins satisfied the IHS criteria for migraine without aura (MO), and of these, 432 (13%) female and 166 (6%) male twins satisfied the criteria for migraine with aura (MA) as indicated by visual symptoms. Latent class analysis (LCA) of IHS symptoms identified three major symptomatic classes, representing 1) a mild form of recurrent nonmigrainous headache, 2) a moderately severe form of migraine, typically without visual aura symptoms (although 40% of individuals in this class were positive for aura), and 3) a severe form of migraine typically with visual aura symptoms (although 24% of individuals were negative for aura). Using the LCA classification, many more individuals were considered affected to some degree than when using IHS criteria (35% vs. 13%). Furthermore, genetic model fitting indicated a greater genetic contribution to migraine using the LCA classification (heritability, h(2)=0.40; 95% CI, 0.29-0.46) compared with the IHS classification (h(2)=0.36; 95% CI, 0.22-0.42). Exploratory latent class modeling, fitting up to 10 classes, did not identify classes corresponding to either the IHS MO or MA classification. Our data indicate the existence of a continuum of severity, with MA more severe but not etiologically distinct from MO. In searching for predisposing genes, we should therefore expect to find some genes that may underlie all major recurrent headache subtypes, with modifying genetic or environmental factors that may lead to differential expression of the liability for migraine.

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ID Code: 92167
Item Type: Journal Article
Refereed: Yes
Additional Information: Nyholt, Dale R
Gillespie, Nathan G
Heath, Andrew C
Merikangas, Kathleen R
Duffy, David L
Martin, Nicholas G
eng
AA07728/AA/NIAAA NIH HHS/
AA10249/AA/NIAAA NIH HHS/
AA11998/AA/NIAAA NIH HHS/
Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
2004/03/17 05:00
Genet Epidemiol. 2004 Apr;26(3):231-44.
Keywords: Adult, Female, Humans, Male, Migraine with Aura/classification/*genetics/pathology, Migraine without Aura/classification/diagnosis/genetics/pathology, Models, Genetic, Severity of Illness Index, Twins/genetics
DOI: 10.1002/gepi.10311
ISSN: 0741-0395
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Wiley-Liss Inc.
Deposited On: 22 Jan 2016 02:02
Last Modified: 22 Jan 2016 02:02

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