A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
Nyholt, D.R. (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. The American Journal of Human Genetics, 74(4), pp. 765-769.
In this report, we describe a simple correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of pairwise LD between SNPs. This method provides a useful alternative to more computationally intensive permutation tests. Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor "loadings" after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region.
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|Item Type:||Journal Article|
|Additional Information:||Nyholt, Dale R
Research Support, Non-U.S. Gov't
Am J Hum Genet. 2004 Apr;74(4):765-9. Epub 2004 Mar 2.
|Keywords:||Gene Frequency/genetics, Haplotypes/genetics, Humans, Internet, Linkage Disequilibrium/*genetics, Polymorphism, Single Nucleotide/*genetics, Probability, Research Design, Software|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2004 The American Society of Human Genetics|
|Deposited On:||22 Jan 2016 01:59|
|Last Modified:||22 Jan 2016 01:59|
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