Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners

Simonic, I., Nyholt, D.R., Gericke, G. S., Gordon, D., Matsumoto, N., Ledbetter, D. H., Ott, J., & Weber, J. L. (2001) Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners. American Journal of Medical Genetics, 105(2), pp. 163-167.

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Utilizing DNA samples from 91 Afrikaner nuclear families with one or more affected children, five genomic regions on chromosomes 2p, 8q, 11q, 20q, and 21q that gave evidence for association with GTS in previous case-control association studies were investigated for linkage and association with GTS. Highly polymorphic markers with mean heterozygosity of 0.77 were typed and resulting genotypes evaluated using single marker transmission disequilibrium (TDT), single marker haplotype relative risk (HRR), and multi-marker "extended" TDT and HRR methods. Single marker TDT analysis showed evidence for linkage or association, with p-values near 0.05, for markers D2S139, GATA28F12, and D11S1377 on chromosomes 2p11, 8q22 and 11q23-24, respectively. Extended, two-locus TDT and HRR analysis provided further evidence for linkage or association on chromosome 2 with p-values of 0.007 and 0.025, and chromosome 8 with p-values of 0.059 and 0.013, respectively. These results provide important additional evidence for the location of GTS susceptibility loci.

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ID Code: 92176
Item Type: Journal Article
Refereed: Yes
Additional Information: Simonic, I
Nyholt, D R
Gericke, G S
Gordon, D
Matsumoto, N
Ledbetter, D H
Ott, J
Weber, J L
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
2001/04/17 10:00
Am J Med Genet. 2001 Mar 8;105(2):163-7.
Keywords: Case-Control Studies, *Chromosomes, Human, Pair 11, *Chromosomes, Human, Pair 2, *Chromosomes, Human, Pair 8, Ethnic Groups/genetics, European Continental Ancestry Group/*genetics, Family Health, *Genetic Linkage, Genetic Markers, *Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Microsatellite Repeats/genetics, Models, Genetic, Netherlands/ethnology, Polymerase Chain Reaction, Polymorphism, Genetic, South Africa, Tourette Syndrome/*ethnology/*genetics
ISSN: 0148-7299
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2001 Wiley-Liss, Inc
Deposited On: 27 Jan 2016 06:21
Last Modified: 27 Jan 2016 06:21

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