Marker selection by Akaike information criterion and Bayesian information criterion
Li, W. & Nyholt, D.R. (2001) Marker selection by Akaike information criterion and Bayesian information criterion. Genetic Epidemiology, 21 Suppl, S272-S277.
We carried out a discriminant analysis with identity by descent (IBD) at each marker as inputs, and the sib pair type (affected-affected versus affected-unaffected) as the output. Using simple logistic regression for this discriminant analysis, we illustrate the importance of comparing models with different number of parameters. Such model comparisons are best carried out using either the Akaike information criterion (AIC) or the Bayesian information criterion (BIC). When AIC (or BIC) stepwise variable selection was applied to the German Asthma data set, a group of markers were selected which provide the best fit to the data (assuming an additive effect). Interestingly, these 25-26 markers were not identical to those with the highest (in magnitude) single-locus lod scores.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Li, W
Nyholt, D R
K01HG00024/HG/NHGRI NIH HHS/
MH44292/MH/NIMH NIH HHS/
Research Support, U.S. Gov't, P.H.S.
Genet Epidemiol. 2001;21 Suppl 1:S272-7.
|Keywords:||Adult, Asthma/epidemiology/*genetics, Bayes Theorem, Child, Discriminant Analysis, Female, Genetic Markers/*genetics, Genetics, Population, Humans, Male, Models, Genetic, Pedigree|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2001 Wiley|
|Deposited On:||27 Jan 2016 05:16|
|Last Modified:||27 Jan 2016 05:41|
Repository Staff Only: item control page