Evidence for an X-linked genetic component in familial typical migraine

Nyholt, D. R., Dawkins, J. L., Brimage, P. J., Goadsby, P. J., Nicholson, G. A., & Griffiths, L. R. (1998) Evidence for an X-linked genetic component in familial typical migraine. Human Molecular Genetics, 7(3), pp. 459-463.

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Migraine is a common complex disorder that shows strong familial aggregation. There is a general increased prevalence of migraine in females compared with males, with recent studies indicating that migraine affects 18% of females compared with 6% of males. This preponderance of females among migraine sufferers coupled with evidence of an increased risk of migraine in first degree relatives of male probands but not in relatives of female probands suggests the possibility of an X-linked dominant gene. We report here the localization of a typical migraine susceptibility locus to the X chromosome. Of three large multigenerational migraine pedigrees two families showed significant excess allele sharing to Xq markers (P = 0.031 and P = 0.012). Overall analysis of data from all three pedigrees gave significant evidence in support of linkage and heterogeneity (HLOD = 3.1). These findings provide conclusive evidence that familial typical migraine is a heterogeneous disorder. We suggest that the localization of a migraine susceptibility locus to the X chromosome could in part explain the increased risk of migraine in relatives of male probands and may be involved in the increased female prevalence of this disorder.

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ID Code: 92184
Item Type: Journal Article
Refereed: Yes
Additional Information: Nyholt, D R
Dawkins, J L
Brimage, P J
Goadsby, P J
Nicholson, G A
Griffiths, L R
Wellcome Trust/United Kingdom
Research Support, Non-U.S. Gov't
Hum Mol Genet. 1998 Mar;7(3):459-63.
Keywords: Alleles, Chromosome Mapping, Disease Susceptibility, Female, Genes, Dominant, Genetic Linkage, Genetic Markers, Humans, Lod Score, Male, Migraine Disorders/*genetics, Pedigree, Statistics, Nonparametric, *X Chromosome
DOI: 10.1093/hmg/7.3.459
ISSN: 0964-6906
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1998 Oxford University Press
Deposited On: 27 Jan 2016 05:06
Last Modified: 27 Jan 2016 05:06

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