Association of a low density lipoprotein receptor microsatellite variant with obesity
Rutherford, S., Nyholt, D. R., Curtain, R. P., Quinlan, S. R., Gaffney, P. T., Morris, B. J., & Griffiths, L. R. (1997) Association of a low density lipoprotein receptor microsatellite variant with obesity. International Journal of Obesity, 21(11), pp. 1032-1037.
OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity.
DESIGN: A cross-sectional case-control study.
SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) > or = 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2.
MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp).
RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (chi 2 = 12.3, P = 0.002), but not in males (chi 2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese.
CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Rutherford, S
Nyholt, D R
Curtain, R P
Quinlan, S R
Gaffney, P T
Morris, B J
Griffiths, L R
Research Support, Non-U.S. Gov't
Int J Obes Relat Metab Disord. 1997 Nov;21(11):1032-7.
|Keywords:||Alleles, Analysis of Variance, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Female, Genotype, Humans, Hypertension/genetics, Lipids/blood, Male, Microsatellite Repeats/*genetics, Obesity/blood/complications/*genetics, Polymorphism, Genetic/*genetics, Receptors, LDL/*genetics|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1997 Stockton Press|
|Deposited On:||27 Jan 2016 04:47|
|Last Modified:||27 Jan 2016 04:53|
Repository Staff Only: item control page