Association of a low density lipoprotein receptor microsatellite variant with obesity

Rutherford, S., Nyholt, D. R., Curtain, R. P., Quinlan, S. R., Gaffney, P. T., Morris, B. J., & Griffiths, L. R. (1997) Association of a low density lipoprotein receptor microsatellite variant with obesity. International Journal of Obesity, 21(11), pp. 1032-1037.

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Abstract

OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity.

DESIGN: A cross-sectional case-control study.

SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) > or = 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2.

MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp).

RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (chi 2 = 12.3, P = 0.002), but not in males (chi 2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese.

CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.

Impact and interest:

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18 citations in Web of Science®

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ID Code: 92186
Item Type: Journal Article
Refereed: Yes
Additional Information: Rutherford, S
Nyholt, D R
Curtain, R P
Quinlan, S R
Gaffney, P T
Morris, B J
Griffiths, L R
eng
Comparative Study
Research Support, Non-U.S. Gov't
ENGLAND
1997/11/22
Int J Obes Relat Metab Disord. 1997 Nov;21(11):1032-7.
Keywords: Alleles, Analysis of Variance, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Female, Genotype, Humans, Hypertension/genetics, Lipids/blood, Male, Microsatellite Repeats/*genetics, Obesity/blood/complications/*genetics, Polymorphism, Genetic/*genetics, Receptors, LDL/*genetics
DOI: 10.1038/sj.ijo.0800512
ISSN: 0307-0565
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 Stockton Press
Deposited On: 27 Jan 2016 04:47
Last Modified: 27 Jan 2016 04:53

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