Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives

Griffiths, L. R., Nyholt, D. R., Curtain, R. P., Gaffney, P. T., & Morris, B. J. (1995) Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives. Clinical and Experimental Pharmacology & Physiology, 22(6-7), pp. 496-498.

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Abstract

  1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations.

  2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives.

  3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.

Impact and interest:

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19 citations in Web of Science®

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ID Code: 92189
Item Type: Journal Article
Refereed: Yes
Additional Information: Griffiths, L R
Nyholt, D R
Curtain, R P
Gaffney, P T
Morris, B J
eng
Comparative Study
Research Support, Non-U.S. Gov't
AUSTRALIA
1995/06/01
Clin Exp Pharmacol Physiol. 1995 Jun-Jul;22(6-7):496-8.
Keywords: Chi-Square Distribution, Cholesterol/*blood, Cross-Sectional Studies, DNA, Satellite/genetics, Electrophoresis, Polyacrylamide Gel, Genetic Markers, Genotype, Humans, Hypertension/etiology/physiopathology, Obesity/*etiology/physiopathology, Polymerase Chain Reaction, Polymorphism, Genetic, Receptors, LDL/*genetics, Repetitive Sequences, Nucleic Acid
DOI: 10.1111/j.1440-1681.1995.tb02056.x
ISSN: 0305-1870
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1995 Wiley-Blackwell Publishing Asia
Deposited On: 27 Jan 2016 23:14
Last Modified: 27 Jan 2016 23:14

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