Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives

Griffiths, L. R., Nyholt, D. R., Curtain, R. P., Gaffney, P. T., & Morris, B. J. (1995) Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives. Clinical and Experimental Pharmacology & Physiology, 22(6-7), pp. 496-498.

View at publisher


  1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations.

  2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives.

  3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.

Impact and interest:

16 citations in Scopus
Search Google Scholar™
19 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 92189
Item Type: Journal Article
Refereed: Yes
Additional Information: Griffiths, L R
Nyholt, D R
Curtain, R P
Gaffney, P T
Morris, B J
Comparative Study
Research Support, Non-U.S. Gov't
Clin Exp Pharmacol Physiol. 1995 Jun-Jul;22(6-7):496-8.
Keywords: Chi-Square Distribution, Cholesterol/*blood, Cross-Sectional Studies, DNA, Satellite/genetics, Electrophoresis, Polyacrylamide Gel, Genetic Markers, Genotype, Humans, Hypertension/etiology/physiopathology, Obesity/*etiology/physiopathology, Polymerase Chain Reaction, Polymorphism, Genetic, Receptors, LDL/*genetics, Repetitive Sequences, Nucleic Acid
DOI: 10.1111/j.1440-1681.1995.tb02056.x
ISSN: 0305-1870
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1995 Wiley-Blackwell Publishing Asia
Deposited On: 27 Jan 2016 23:14
Last Modified: 27 Jan 2016 23:14

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page