Assessment of the severity of Ebola virus disease in Sierra Leone in 2014–2015

Wong, J.Y., Zhang, W., Kargbo, D., Haque, U., Hu, W., Wu, P., Kamara, A., Chen, Y., Kargbo, B., Glass, G.E., Yang, R., Cowling, B.J., & Liu, C. (2016) Assessment of the severity of Ebola virus disease in Sierra Leone in 2014–2015. Epidemiology and Infection, 144(7), pp. 1473-1481.

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Abstract

The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6–75·5] and 68·9% (95% CrI 66·2–71·6), respectively. Risks of death were higher in the youngest (0–4 years) and oldest (≥60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.

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5 citations in Web of Science®
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ID Code: 92264
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Death, Ebola virus, Severity
DOI: 10.1017/S0950268815003003
ISSN: 1469-4409
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2015 Cambridge University Press
Deposited On: 25 Jan 2016 01:55
Last Modified: 06 May 2016 03:15

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