Cord blood 25-hydroxyvitamin D and fetal growth in the China-Anhui birth cohort study

Zhu, Peng, Tong, Shilu, Hu, Wenbiao, Hao, Jia-hu, Tao, Rui-xue, Huang, Kun, Mou, Zhe, Zhou, Qi-fan, Jiang, Xiao-min, & Tao, Fang-biao (2015) Cord blood 25-hydroxyvitamin D and fetal growth in the China-Anhui birth cohort study. Scientific Reports, 5, Article Number-14930.

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We determined the association of cord blood 25-hydroxyvitamin D [25(OH)D] with birth weight and the risk of small for gestational age (SGA). As part of the China-Anhui Birth Cohort (C-ABC) study, we measured cord blood levels of 25(OH)D in 1491 neonates in Hefei, China. The data on maternal sociodemographic characteristics, health status, lifestyle, birth outcomes were prospectively collected. Multiple regression models were used to estimate the association of 25(OH)D levels with birth weight and the risk of SGA. Compared with neonates in the lowest decile of cord blood 25(OH)D levels, neonates in four deciles (the fourth, fifth, sixth and seventh deciles) had significantly increased birth weight and decreased risk of SGA. Multiple linear regression models showed that per 10 nmol/L increase in cord blood 25(OH)D, birth weight increased by 61.0 g (95% CI: 31.9, 89.9) at concentrations less than 40 nmol/L, and then decreased by 68.5 g (95% CI: −110.5, −26.6) at concentrations from 40 to 70 nmol/L. This study provides the first epidemiological evidence that there was an inverted U shaped relationship between neonatal vitamin D status and fetal growth, and the risk of SGA reduced at moderate concentration.

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ID Code: 92266
Item Type: Journal Article
Refereed: Yes
Keywords: Birth Cohort Study, 25-hydroxyvitamin D, Fetal Growth
DOI: 10.1038/srep14930
ISSN: 2045-2322
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 The Author(s)
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The
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Deposited On: 25 Jan 2016 06:33
Last Modified: 06 May 2016 04:22

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