Development of immunotherapies and vaccines against visceral leishmaiasis

Faleiro, Rebecca Jacinto (2016) Development of immunotherapies and vaccines against visceral leishmaiasis. PhD thesis, Queensland University of Technology.

Abstract

Visceral leishmaniasis (VL) is a chronic parasitic disease prevalent in tropical and sub- tropical countries. This study focused on the development of immune-based therapy with immune checkpoint inhibitors and/or activators, as well as cytokines as a way to treat VL either alone or in combination with conventional drugs. Since many chronic infectious diseases share mechanisms of immune suppression, these findings have broader implications for other infectious diseases, such as HIV, tuberculosis and malaria.

Impact and interest:

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21 since deposited on 31 Mar 2016
21 in the past twelve months

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ID Code: 92285
Item Type: QUT Thesis (PhD)
Supervisor: Hafner, Louise & Huston, Willa
Keywords: CD4+ T cells, Leishmania, Visceral leishmaniasis, Immunetherapy, Vaccines
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 31 Mar 2016 00:37
Last Modified: 31 Mar 2016 00:37

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