The validation of profluorescent nitroxides as potential probes to monitor mitochondrial oxidative stress

Chong, Kok Leong (2016) The validation of profluorescent nitroxides as potential probes to monitor mitochondrial oxidative stress. PhD thesis, Queensland University of Technology.


In cells, the balance of oxidation and reduction reactions (redox chemistry) plays a significant role in key biological processes such as cell signaling, cell fate determination and the body's defence systems, all of which contribute significantly to the overall well-being of the body. This project served as a step forward in developing a more efficient method to monitor mitochondrial redox status. The method is based on the application of profluorescent nitroxides (PFN) that change in fluorescent intensity based on changing mitochondrial redox status. A major impact of this project is to facilitate assessment of mitochondrial redox status and thereby determine the efficacy of antioxidant treatments.

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ID Code: 92513
Item Type: QUT Thesis (PhD)
Supervisor: Bottle, Steven & Fairfull-Smith, Kathryn
Keywords: Antioxidant, Fluorescence, Fluorescent Probe, Free Radicals, Mitochondria, Profluorescent
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 31 Mar 2016 02:19
Last Modified: 31 Mar 2016 02:19

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