Assessing the combined effect of asbestos exposure and smoking on lung cancer: a Bayesian approach

Wraith, D. & Mengersen, K. (2007) Assessing the combined effect of asbestos exposure and smoking on lung cancer: a Bayesian approach. Statistics in Medicine, 26(5), pp. 1150-1169.

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Abstract

We review the literature on the combined association between lung cancer and two environmental exposures, asbestos exposure and smoking, and explore a Bayesian approach to assess evidence of interaction between the exposures. The meta-analysis combines separate indices of additive and multiplicative relationships and multivariate relative risk estimates. By making inferences on posterior probabilities we can explore both the form and strength of interaction. This analysis may be more informative than providing evidence to support one relation over another on the basis of statistical significance. Overall, we find evidence for a more than additive and less than multiplicative relation.

Impact and interest:

19 citations in Scopus
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18 citations in Web of Science®

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ID Code: 92586
Item Type: Journal Article
Refereed: Yes
Keywords: Bayesian; interaction; meta-analysis; asbestos; smoking; lung cancer
DOI: 10.1002/sim.2602
ISSN: 1097-0258
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Current > Schools > School of Public Health & Social Work
Deposited On: 04 Feb 2016 00:50
Last Modified: 05 Feb 2016 01:19

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