Monitoring healing progression and characterizing the mechanical environment in preclinical models for bone tissue engineering
Fountain, Stephanie, Windolf, Markus, Henkel, Jan, Tavakoli, Aramesh, Schuetz, Michael A., Hutmacher, Dietmar W., & Epari, Devakara R. (2016) Monitoring healing progression and characterizing the mechanical environment in preclinical models for bone tissue engineering. Tissue Engineering Part B: Reviews, 22(1), pp. 47-57.
The treatment of large segmental bone defects remains a significant clinical challenge. Due to limitations surrounding the use of bone grafts, tissue-engineered constructs for the repair of large bone defects could offer an alternative. Before translation of any newly developed tissue engineering (TE) approach to the clinic, efficacy of the treatment must be shown in a validated preclinical large animal model. Currently, biomechanical testing, histology, and microcomputed tomography are performed to assess the quality and quantity of the regenerated bone. However, in vivo monitoring of the progression of healing is seldom performed, which could reveal important information regarding time to restoration of mechanical function and acceleration of regeneration. Furthermore, since the mechanical environment is known to influence bone regeneration, and limb loading of the animals can poorly be controlled, characterizing activity and load history could provide the ability to explain variability in the acquired data sets and potentially outliers based on abnormal loading. Many approaches have been devised to monitor the progression of healing and characterize the mechanical environment in fracture healing studies. In this article, we review previous methods and share results of recent work of our group toward developing and implementing a comprehensive biomechanical monitoring system to study bone regeneration in preclinical TE studies.
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|Item Type:||Journal Article|
|Keywords:||tissue engineering, bone, mechanical environment|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright Mary Ann Liebert, Inc|
|Deposited On:||03 Feb 2016 00:48|
|Last Modified:||03 Mar 2016 07:02|
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