Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease

Deng, Yifu, Newman, Beth M., Dunne, Michael P., Silburn, Peter A., & Mellick, George D. (2004) Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease. Annals Of Neurology, 55(6), p. 897.

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Background and aims: Recent studies on appendicectomy rates in ulcerative colitis and Crohn's disease have generally not addressed the effect of appendicectomy on disease characteristics. The aims of this study were to compare appendicectomy rates in Australian inflammatory bowel disease patients and matched controls, and to evaluate the effect of prior appendicectomy on disease characteristics.

Methods: Patients were ascertained from the Brisbane Inflammatory Bowel Disease database. Controls matched for age and sex were randomly selected from the Australian Twin Registry. Disease characteristics included age at diagnosis, disease site, need for immunosuppression, and intestinal resection.

Results: The study confirmed the significant negative association between appendicectomy and ulcerative colitis (odds ratio (OR) 0.23, 95% confidence interval (Cl) 0.14-0.38; p<0.0001) and found a similar result for Crohn's disease once the bias of appendicectomy at diagnosis was addressed (OR 0.34, 95% Cl 0.23-0.51; p<0.0001). Prior appendicectomy delayed age of presentation far both diseases and was statistically significant for Crohn's disease (p=0.02). In ulcerative colitis, patients with prior appendicectomy had clinically milder disease with reduced requirement for immunosuppression (OR 0.15, 95% Cl 0.02-1.15; p=0.04) and proctocolectomy (p=0.02)

Conclusions: Compared with patients without prior appendicectomy, appendicectomy before diagnosis delays disease onset in ulcerative colitis and Crohn's disease and gives rise to a milder disease phenotype in ulcerative colitis.

Impact and interest:

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ID Code: 9265
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author.
Keywords: Risk, Cytochrome P, 450 CYP2D6/, genetics Parkinson Disease/, etiology Pesticide Residues/, toxicity Aged, Aged, 80 and over, Alleles, Case, Control Studies, Cytochrome P, 450 CYP2D6/metabolism, Dose, Response Relationship, Drug, Female, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease/genetics, Polymorphism, Restriction Fragment Length, RNA, Messenger/biosynthesis, Random Allocation, Reverse Transcriptase Polymerase Chain Reaction/methods
DOI: 10.1002/ana.20143
ISSN: 0364-5134
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 John Wiley & Sons
Deposited On: 03 Sep 2007 00:00
Last Modified: 10 Aug 2011 16:07

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