Determination of the kallikrein-related peptidase 7 degradome and Transciptome in ovarian cancer

Silva, Munasinghage Lakmali (2016) Determination of the kallikrein-related peptidase 7 degradome and Transciptome in ovarian cancer. PhD thesis, Queensland University of Technology.


Ovarian cancer is the leading cause of cancer-related death in women, and the need for curative treatments is urgent. This study characterised an enzyme associated with the most lethal form of ovarian cancer, showing this enzyme to be a promising therapeutic target. Fifteen novel protein targets and key signalling pathways were determined to be regulated by this enzyme, kallikrein-related peptidase 7, in the ovarian tumour microenvironment, highlighting its involvement in cancer progression. Inhibition of this enzyme may be a useful therapeutic option to improve the life expectancy of women suffering from this cancer.

Impact and interest:

Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

107 since deposited on 13 Apr 2016
77 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 92869
Item Type: QUT Thesis (PhD)
Supervisor: Clements, Judith, Dong, Ying, & Irving-Rodgers, Helen
Keywords: Cancer, Degradome, Extracellular, High-grade serous ovarian, Kallikrein-related peptidase, Matrix metalloprotease, Proteomics, Thrombospondin, Transcriptomics, Microenvironment
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 13 Apr 2016 07:23
Last Modified: 21 Jun 2017 14:52

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page