Determination of the kallikrein-related peptidase 7 degradome and Transciptome in ovarian cancer
Silva, Munasinghage Lakmali (2016) Determination of the kallikrein-related peptidase 7 degradome and Transciptome in ovarian cancer. PhD thesis, Queensland University of Technology.
Ovarian cancer is the leading cause of cancer-related death in women, and the need for curative treatments is urgent. This study characterised an enzyme associated with the most lethal form of ovarian cancer, showing this enzyme to be a promising therapeutic target. Fifteen novel protein targets and key signalling pathways were determined to be regulated by this enzyme, kallikrein-related peptidase 7, in the ovarian tumour microenvironment, highlighting its involvement in cancer progression. Inhibition of this enzyme may be a useful therapeutic option to improve the life expectancy of women suffering from this cancer.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Clements, Judith, Dong, Ying, & Irving-Rodgers, Helen|
|Keywords:||Cancer, Degradome, Extracellular, High-grade serous ovarian, Kallikrein-related peptidase, Matrix metalloprotease, Proteomics, Thrombospondin, Transcriptomics, Microenvironment|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||13 Apr 2016 07:23|
|Last Modified:||13 Apr 2016 07:23|
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