Plasma polymer and biomolecule modification of 3-D scaffolds for tissue engineering

Robinson, David, Al-Bataineh, Sameer, Farrugia, Brooke L., Michelmore, Andrew, Cowin, Allison, Dargaville, Tim R., Short, Robert, Smith, Louise, & Whittle, Jason D. (2016) Plasma polymer and biomolecule modification of 3-D scaffolds for tissue engineering. Plasma Processes and Polymers. (In Press)

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Plasma polymerization was used to coat a melt electrospun polycaprolactone scaffold to improve cell attachment and organization. Plasma polymerization was performed using an amine containing monomer, allylamine, which then allowed for the subsequent immobilization of biomolecules i.e. heparin and fibroblast growth factor-2. The stability of the plasma polymerized amine-coating was demonstrated by X-ray photoelectron spectroscopy analysis and imaging time-of-flight secondary ion mass spectrometry revealed that a uniform plasma amine-coating was deposited throughout the scaffold. Based upon comparison with controls it was evident that the combination scaffold aided cell ingress and the formation of distinct fibroblast and keratinocyte layers.

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ID Code: 93072
Item Type: Journal Article
Refereed: Yes
Keywords: Plasma polymerization, Scaffold modification, glycosaminoglycan, Electrospinning, Skin Construct
DOI: 10.1002/ppap.201500162
ISSN: 1612-8869
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300) > Macromolecular and Materials Chemistry not elsewhere classified (030399)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 19 Feb 2016 03:18
Last Modified: 25 Feb 2016 10:35

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