Artificial Neural Network Analysis of DNA Microarray-based Prostate Cancer Recurrence
Peterson, Leif E., Ozen, Mustafa, Erdem, Halime, Amini, Andrew, Gomez, Lori, Nelson, Colleen C., & Ittmann, Michael (2005) Artificial Neural Network Analysis of DNA Microarray-based Prostate Cancer Recurrence. In 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 14-15 Novermber 2005, San Diego, California.
DNA microarray-based gene expression profiles have been established for a variety of adult cancers. This paper addresses application of an artificial neural network (ANN) with leave-one-out testsing and 8-fold cross-validation for analyzing DNA microarray data to identify genes predictive of recurrence after prostatectomy. Among 725 genes screened for ANN input, a 16-gene model resulted in 99-100% diagnostic sensitivity and specificity: DGCR5, FLJ10618, RIS1, PRO1855, ABCB9, AK057203, GOLGA5, HARS, AK024152, HEP27, PPIA, SNRPF, SULT1A3, SECTM1, EIF4EBP1, and S71435. Genes identified with ANN that are prognostic of prostate cancer recurrence may be either causal for prostate cancer or secondary to the disease. Nevertheless, the genes identified may be confirmed in the future to be markers of early detection and/or therapy.
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
|Item Type:||Conference Paper|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2005 IEEE|
|Copyright Statement:||Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.|
|Deposited On:||04 Sep 2007|
|Last Modified:||09 Jun 2010 22:45|
Repository Staff Only: item control page