Short and long term mortality rates after a lower limb amputation

Fortington, L.V., Geertzen, J.H.B., van Netten, J.J., Postema, K., Rommers, G.M., & Dijkstra, P.U. (2013) Short and long term mortality rates after a lower limb amputation. European Journal of Vascular and Endovascular Surgery, 46(1), pp. 124-131.

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To determine mortality rates after a first lower limb amputation and explore the rates for different subpopulations.


Retrospective cohort study of all people who underwent a first amputation at or proximal to transtibial level, in an area of 1.7 million people. Analysis with Kaplan-Meier curves and Log Rank tests for univariate associations of psycho-social and health variables. Logistic regression for odds of death at 30-days, 1-year and 5-years.


299 people were included. Median time to death was 20.3 months (95%CI: 13.1; 27.5). 30-day mortality = 22%; odds of death 2.3 times higher in people with history of cerebrovascular disease (95%CI: 1.2; 4.7, P = 0.016). 1 year mortality = 44%; odds of death 3.5 times higher for people with renal disease (95%CI: 1.8; 7.0, P < 0.001). 5-years mortality = 77%; odds of death 5.4 times higher for people with renal disease (95%CI: 1.8; 16.0,P = 0.003). Variation in mortality rates was most apparent in different age groups; people 75–84 years having better short term outcomes than those younger and older.


Mortality rates demonstrated the frailty of this population, with almost one quarter of people dying within 30-days, and almost half at 1 year. People with cerebrovascular had higher odds of death at 30 days, and those with renal disease and 1 and 5 years, respectively.

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ID Code: 93270
Item Type: Journal Article
Refereed: Yes
Additional Information: Open Access funded by European Society for Vascular Surgery
Keywords: Amputation, Diabetes mellitus, Mortality
DOI: 10.1016/j.ejvs.2013.03.024
ISSN: 1078-5884
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 01 Mar 2016 06:02
Last Modified: 10 Mar 2016 02:06

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