Human and pathogen factors associated with chlamydia trachomatis-related infertility in women

Menon, S., Timms, P., Allan, J.A., Alexander, K., Rombauts, L., Horner, P., Keltz, M., Hocking, J., & Huston, W.M. (2015) Human and pathogen factors associated with chlamydia trachomatis-related infertility in women. Clinical Microbiology Reviews, 28(4), pp. 969-985.

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Abstract

Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen worldwide. Infection can result in serious reproductive pathologies, including pelvic inflammatory disease, ectopic pregnancy, and infertility, in women. However, the processes that result in these reproductive pathologies have not been well defined. Here we review the evidence for the human disease burden of these chlamydial reproductive pathologies. We then review human-based evidence that links Chlamydia with reproductive pathologies in women. We present data supporting the idea that host, immunological, epidemiological, and pathogen factors may all contribute to the development of infertility. Specifically, we review the existing evidence that host and pathogen genotypes, host hormone status, age of sexual debut, sexual behavior, coinfections, and repeat infections are all likely to be contributory factors in development of infertility. Pathogen factors such as infectious burden, treatment failure, and tissue tropisms or ascension capacity are also potential contributory factors. We present four possible processes of pathology development and how these processes are supported by the published data. We highlight the limitations of the evidence and propose future studies that could improve our understanding of how chlamydial infertility in women occurs and possible future interventions to reduce this disease burden.

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ID Code: 93276
Item Type: Journal Article
Refereed: Yes
DOI: 10.1128/CMR.00035-15
ISSN: 1098-6618
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Nursing not elsewhere classified (111099)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2015 American Society for Microbiology
Deposited On: 25 Feb 2016 23:36
Last Modified: 02 Mar 2016 03:31

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