Longitudinal changes in choroidal thickness and eye growth in childhood

Read, Scott A., Alonso-Caneiro, David, Vincent, Stephen J., & Collins, Michael J. (2015) Longitudinal changes in choroidal thickness and eye growth in childhood. Investigative Ophthalmology and Visual Science, 56(5), pp. 3103-3112.

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Abstract

PURPOSE

To examine longitudinal changes in choroidal thickness and axial length in a population of children with a range of refractive errors.

METHODS

One hundred and one children (41 myopes and 60 nonmyopes) aged 10 to 15 years participated in this prospective, observational longitudinal study. For each child, 6-month measures of choroidal thickness (using enhanced depth imaging optical coherence tomography) and axial ocular biometry were collected four times over an 18-month period. Linear mixed-models were used to examine the longitudinal changes in choroidal thickness and the relationship between changes in choroidal thickness and axial eye growth over the study period.

RESULTS

A significant group mean increase in subfoveal choroidal thickness was observed over 18 months (mean increase 13 6 22 lm, P < 0.001). Myopic children exhibited significantly thinner choroids compared with nonmyopic children (P < 0.001), although there was no significant time by refractive group interaction (P ¼ 0.46), indicating similar changes in choroidal thickness over time in myopes and nonmyopes. However, a significant association between the change in choroidal thickness and the change in axial length over time was found (P < 0.001, β = −0.14). Children showing faster axial eye growth exhibited significantly less choroidal thickening over time compared with children showing slower axial eye growth.

CONCLUSIONS

A significant increase in choroidal thickness occurs over an 18-month period in normal 10- to 15-year-old children. Children undergoing faster axial eye growth exhibited less thickening and, in some cases, a thinning of the choroid. These findings support a potential role for the choroid in the mechanisms regulating eye growth in childhood.

Impact and interest:

5 citations in Scopus
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4 citations in Web of Science®

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ID Code: 93313
Item Type: Journal Article
Refereed: Yes
Keywords: childhood, choroid, myopia, refractive error, optical coherence tomography
DOI: 10.1167/iovs.15-16446
ISSN: 1552-5783
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Funding:
Copyright Owner: Copyright 2015 Association for Research in Vision and Ophthalmology
Deposited On: 01 Mar 2016 05:07
Last Modified: 05 Mar 2016 08:32

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