Positive associations of serum Perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan
Qin, Xiao-Di, Qian, Zhengmin, Vaughn, Michael, Huang, Jin, Ward, Patrick, Zeng, Xiao-Wen, Zhou, Yang, Zhu, Yu, Yuan, Ping, Li, Meng, Bai, Zhipeng, Paul, Gunther, Hao, Yuan-Tao, Chen, Wen, Chen, Pau-Chung, Dong, Guang-Hui, & Lee, Yungling Leo (2016) Positive associations of serum Perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution, 212, pp. 519-524.
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To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in > 94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β=0.1463, p<0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR=2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR=2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.
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|Item Type:||Journal Article|
|Keywords:||perfluoroalkyl substances, uric acid, hyperuricemia, child|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Community Child Health (111704)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Environmental and Occupational Health and Safety (111705)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
|Copyright Owner:||Copyright 2016 Elsevier|
|Deposited On:||10 Mar 2016 04:17|
|Last Modified:||14 Apr 2016 20:57|
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