Higher-resolution structure of the human insulin receptor ectodomain: Multi-modal inclusion of the insert domain
Croll, Tristan I., Smith, Brian J., Margetts, Mai B., Whittaker, Jonathan, Weiss, Michael A., Ward, Colin W., Lawrence, Michael C., , & (2016) Higher-resolution structure of the human insulin receptor ectodomain: Multi-modal inclusion of the insert domain. Structure, 24(3), pp. 469-476.
Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 Å) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we revise this structure using new diffraction data to 3.3 Å resolution that allow improved modeling of the N-linked glycans, the first and third fibronectin type III domains, and the insert domain. A novel haptic interactive molecular dynamics strategy was used to aid fitting to low-resolution electron density maps. The resulting model provides a foundation for investigation of structural transitions in IR upon ligand binding.
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Facilities:||HPC – QUT Supercomputer|
|Deposited On:||14 Mar 2016 03:14|
|Last Modified:||22 Aug 2016 03:05|
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