Photocrosslinkable hydrogels for cartilage tissue engineering

Levett, Peter A. (2016) Photocrosslinkable hydrogels for cartilage tissue engineering. PhD by Publication, Queensland University of Technology.

Abstract

For millions of people, damaged cartilage is a major source of pain and disability. Once damaged, cartilage heals very poorly and the ongoing clinical management is challenging. This thesis advances our understanding of the potential for cartilage to be repaired using tissue engineering methods. In particular, it broadens the range of materials that can be used and shows the importance of material selection for a successful outcome. The hydrogels used in this thesis were made predominantly from gelatin combined with targeted additives, which were chemically modified to allow them to be crosslinked by light. The optimal combination gelatin and hyaluronic acid greatly improved the mechanical properties of tissue-engineered cartilage. In addition, the cells encapsulated in these materials were healthier and produced higher quality cartilage. Together, these benefits increase the chance of success in clinical applications.

Impact and interest:

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13 since deposited on 05 Jul 2016
13 in the past twelve months

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ID Code: 93811
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Klein, Travis, Hutmacher, Dietmar, & Malda, Jos
Keywords: Tissue engineering, Cartilage, Hydrogels, Hyaluronic acid, Gelatin
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 05 Jul 2016 06:58
Last Modified: 05 Jul 2016 06:58

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