Oxazolidine-2-thiones: A molecular modeling study

Gandhi, Neha, Srivastava, Brijesh K., Lohray, Vidya B., & Lohray, Braj B. (2004) Oxazolidine-2-thiones: A molecular modeling study. Tetrahedron Letters, 45(33), pp. 6269-6272.

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Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.

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15 citations in Web of Science®

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ID Code: 93824
Item Type: Journal Article
Refereed: Yes
Keywords: Oxazolidine-2-thiones; Linezolid; Molecular modeling; 23S rRNA; Antibacterial; Piecewise linear potential (PLP); Thioacetamide
DOI: 10.1016/j.tetlet.2004.06.090
ISSN: 0040-4039
Divisions: Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2004 Elsevier Ltd.
Deposited On: 04 Apr 2016 23:18
Last Modified: 04 Apr 2016 23:18

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