Oxazolidine-2-thiones: A molecular modeling study
Gandhi, Neha, Srivastava, Brijesh K., Lohray, Vidya B., & Lohray, Braj B. (2004) Oxazolidine-2-thiones: A molecular modeling study. Tetrahedron Letters, 45(33), pp. 6269-6272.
Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.
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|Item Type:||Journal Article|
|Keywords:||Oxazolidine-2-thiones; Linezolid; Molecular modeling; 23S rRNA; Antibacterial; Piecewise linear potential (PLP); Thioacetamide|
|Divisions:||Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2004 Elsevier Ltd.|
|Deposited On:||04 Apr 2016 23:18|
|Last Modified:||04 Apr 2016 23:18|
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