Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

Raval, Saurin, Raval, Preeti, Bandyopadhyay, Debdutta, Soni, Krunal, Yevale, Digambar, Jogiya, Digvijay, Modi, Honey, Joharapurkar, Amit, Gandhi, Neha, Jain, Mukul R., & Patel, Pankaj R. (2008) Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands. Bioorganic & Medicinal Chemistry Letters, 18(14), pp. 3919-3924.

View at publisher

Abstract

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.

Impact and interest:

4 citations in Scopus
Search Google Scholar™
4 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 93840
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.bmcl.2008.06.038
ISSN: 0960-894X
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 04 Apr 2016 22:54
Last Modified: 19 Apr 2016 04:27

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page