Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver

Kenna, Tony, Golden-Mason, Lucy, Norris, Suzanne, Hegarty, John E., O'Farrelly, Cliona, & Doherty, Derek G. (2004) Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver. Clinical Immunology, 113(1), pp. 56-63.

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Gamma delta T cells are thought to mediate immune responses at epithelial surfaces. We have quantified and characterized hepatic and peripheral blood gamma delta T cells from 11 normal and 13 unresolved tumor-bearing human liver specimens. gamma delta T cells are enriched in normal liver (6.6% of T cells) relative to matched blood (0.9%; P = 0.008). The majority express CD4(-)CD8(-) phenotypes and many express CD56 and/or CD161. In vitro, hepatic gamma delta T cells can be induced to kill tumor cell lines and release interferon-gamma, tumor necrosis factor-alpha, interleukin-2 and interleukin-4. Analysis of V gamma and V delta chain usage indicated that V delta 3(+) cells are expanded in normal livers (21.2% of gamma delta T cells) compared to blood (0.5%; P = 0.001). Tumor-bearing livers had significant expansions and depletions of gamma delta T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors.

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ID Code: 94059
Item Type: Journal Article
Refereed: Yes
Keywords: Adolescent, Adult, Aged, Female, Humans, Immunophenotyping, Liver/cytology/ immunology/metabolism, Liver Neoplasms/ immunology/metabolism/pathology, Male, Middle Aged, Receptors, Antigen, T-Cell, gamma-delta/immunology/metabolism, T-Lymphocyte Subsets/ immunology/metabolism
DOI: 10.1016/j.clim.2004.05.003
ISSN: 1521-6616
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Elsevier Inc.
Deposited On: 23 Mar 2016 00:03
Last Modified: 23 Mar 2016 00:03

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