Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis

Kenna, Tony J., Robinson, Philip C., & Haroon, Nigil (2015) Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis. Rheumatology, 54(9), pp. 1549-1556.

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Abstract

There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this manner and are of particular interest. There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules. Recent studies on the structure, immunological effects and the peptide-trimming properties of ERAP 1 and 2 have helped to provide insight into their pathogenic potential in AS. In this review, we explore the role of ERAP 1 and 2 in the pathogenesis of AS. © The Author 2015.

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ID Code: 94064
Item Type: Journal Article
Refereed: Yes
Keywords: Aminopeptidase, Endoplasmic reticulum, Endoplasmic reticulum resident aminopeptidase 1, Endoplasmic reticulum resident aminopeptidase 2, Misfolding, NK cell, Peptide, T cell response, Unfolded protein response, endoplasmic reticulum aminopeptidase 1, endoplasmic reticulum aminopeptidase 2, HLA B27 antigen, unclassified drug, ankylosing spondylitis, balancing selection, cell surface, dendritic cell, disease association, gene frequency, gene interaction, genetic association, haplotype, human, major histocompatibility complex, priority journal, Review, single nucleotide polymorphism
DOI: 10.1093/rheumatology/kev218
ISSN: 1462-0332
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 The Authors
Deposited On: 23 Mar 2016 00:45
Last Modified: 23 Mar 2016 21:40

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