Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses

Kenna, Tony J., Thomas, Ranjeny, & Steptoe, Raymond J. (2008) Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses. Blood, 111(4), pp. 2091-2100.

View at publisher

Abstract

Antigen stimulation of naive T cells in conjunction with strong costimulatory signals elicits the generation of effector and memory populations. Such terminal differentiation transforms naive T cells capable of differentiating along several terminal pathways in response to pertinent environmental cues into cells that have lost developmental plasticity and exhibit heightened responsiveness. Because these cells exhibit little or no need for the strong costimulatory signals required for full activation of naive T cells, it is generally considered memory and effector T cells are released from the capacity to be inactivated. Here, we show that steadystate dendritic cells constitutively presenting an endogenously expressed antigen inactivate fully differentiated memory and effector CD8+ T cells in vivo through deletion and inactivation. These findings indicate that fully differentiated effector and memory T cells exhibit a previously unappreciated level of plasticity and provide insight into how memory and effector T-cell populations may be regulated. © 2008 by The American Society of Hematology.

Impact and interest:

32 citations in Scopus
Search Google Scholar™
30 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 94065
Item Type: Journal Article
Refereed: Yes
Keywords: CD8 antigen, animal cell, antigen expression, antigen presentation, article, CD8+ T lymphocyte, controlled study, dendritic cell, effector cell, lymphocyte differentiation, memory T lymphocyte, mouse, nonhuman, priority journal, signal transduction, steady state, Adoptive Transfer, Animals, CD8-Positive T-Lymphocytes, Crosses, Genetic, Cytokines, Dendritic Cells, Immunologic Memory, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Ovalbumin, Peptide Fragments
DOI: 10.1182/blood-2007-07-103200
ISSN: 0006-4971
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 by The American Society of Hematology
Deposited On: 23 Mar 2016 01:24
Last Modified: 24 Mar 2016 04:15

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page