Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

Upadhyaya, Akanksha, Smith, Robert A., Chacon-Cortes, Diego, Revêchon, Gwladys, Bellis, Claire, Lea, Rod A., Haupt, Larisa M., Chambers, Suzanne K., Youl, Philippa H., & Griffiths, Lyn R. (2016) Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. Gene, 576(1, Part 2), pp. 256-260.

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Abstract

Background

Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation.

Methods

In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting.

Results

Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p = 0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40–2.23).

Conclusions

The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.

Impact and interest:

1 citations in Scopus
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2 citations in Web of Science®

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ID Code: 94369
Item Type: Journal Article
Refereed: Yes
Keywords: MiR146a, polymorphism, breast cancer, BRCA, SNP, MiRNA
DOI: 10.1016/j.gene.2015.10.019
ISSN: 1879-0038
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Elsevier B.V.
Copyright Statement: This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Deposited On: 04 Apr 2016 23:27
Last Modified: 26 Jan 2017 10:34

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