Potential antioxidant response to coffee - A matter of genotype?
Hassmann, Ute, Haupt, Larisa M., Smith, Robert A., Winkler, Swantje, Bytof, Gerhard, Lantz, Ingo, Griffiths, Lyn R., & Marko, Doris (2014) Potential antioxidant response to coffee - A matter of genotype? MetaGene, 2, pp. 525-539.
In a human intervention trial, a coffee, combining nature green coffee bean constituents and dark roast products was studied towards its potential to activate the Nrf2/ARE-pathway in PBLs. The study coffee was identified as a strong inducer of Nrf2 and downstream GST1A1 and UGT1A1 gene transcription. However, the response of the participants was found to depend on the respective genotype. The -651 SNP in the Nrf2 gene as well as the heterozygote 6/7 sequence in the UGT1A1 gene significantly down-regulated the susceptibility to respond to coffee, proposing the existing genotype to be critical for the response to the coffee.
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|Item Type:||Journal Article|
|Keywords:||Reactive oxygen species, antioxidant, coffee, Nrf genotype, GST1A1 genotype, UGT1A1 genotype, genetic variations, gene expression|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||2014 The Author(s)|
|Copyright Statement:||This is an open access
article under the CC BY license
|Deposited On:||05 Apr 2016 04:08|
|Last Modified:||15 Apr 2016 08:38|
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