Potential antioxidant response to coffee - A matter of genotype?

Hassmann, Ute, Haupt, Larisa M., Smith, Robert A., Winkler, Swantje, Bytof, Gerhard, Lantz, Ingo, Griffiths, Lyn R., & Marko, Doris (2014) Potential antioxidant response to coffee - A matter of genotype? MetaGene, 2, pp. 525-539.

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Abstract

In a human intervention trial, a coffee, combining nature green coffee bean constituents and dark roast products was studied towards its potential to activate the Nrf2/ARE-pathway in PBLs. The study coffee was identified as a strong inducer of Nrf2 and downstream GST1A1 and UGT1A1 gene transcription. However, the response of the participants was found to depend on the respective genotype. The -651 SNP in the Nrf2 gene as well as the heterozygote 6/7 sequence in the UGT1A1 gene significantly down-regulated the susceptibility to respond to coffee, proposing the existing genotype to be critical for the response to the coffee.

Impact and interest:

2 citations in Scopus
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ID Code: 94390
Item Type: Journal Article
Refereed: Yes
Keywords: Reactive oxygen species, antioxidant, coffee, Nrf genotype, GST1A1 genotype, UGT1A1 genotype, genetic variations, gene expression
DOI: 10.1016/j.mgene.2014.07.003
ISSN: 2214-5400
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2014 The Author(s)
Copyright Statement: This is an open access
article under the CC BY license
(http://creativecommons.org/licenses/by/3.0/).
Deposited On: 05 Apr 2016 04:08
Last Modified: 15 Apr 2016 08:38

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