Genome-wide association study of prostate cancer-specific survival

Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R.A., Easton, D.F., Kote-Jarai, Z., Al Olama, A.A., Benlloch, S., Muir, K., Giles, G.G., Southey, M.C., FitzGerald, L.M., Henderson, B.E., Schumacher, F.R., Haiman, C.A., Sipeky, C., Tammela, T.L.J., Nordestgaard, B.G., Key, T.J., Travis, R.C., Neal, D.E., Donovan, J.L., Hamdy, F.C., Pharoah, P.D.P., Pashayan, N., Khaw, K.-T., Stanford, J.L., Thibodeau, S.N., McDonnell, S.K., Schaid, D.J., Maier, C., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A.S., Cybulski, C., Lubi ski, J., Klu niak, W., Cannon-Albright, L., Brenner, H., Herrmann, V., Holleczek, B., Park, J.Y., Sellers, T.A., Lim, H.-Y., Slavov, C., Kaneva, R.P., Mitev, V.I., Spurdle, A., Teixeira, M.R., Paulo, P., Maia, S., Pandha, H., Michael, A., Kierzek, A., Batra, J., Clements, J.A., Albanes, D., Andriole, G.L., Berndt, S.I., Chanock, S., Gapstur, S.M., Giovannucci, E.L., Hunter, D.J., Kraft, P., Le Marchand, L., Ma, J., Mondul, A.M., Penney, K.L., Stampfer, M.J., Stevens, V.L., Weinstein, S.J., Trichopoulou, A., Bueno-de-Mesquita, B.H., Tjonneland, A., Cox, D.G., Maehle, L., Schleutker, J., Lindstrom, S., & Wiklund, F. (2015) Genome-wide association study of prostate cancer-specific survival. Cancer Epidemiology, Biomarkers and Prevention, 24(11), pp. 1796-1800.

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Abstract

BACKGROUND:

Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

METHODS:

We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

RESULTS:

We observed no significant association between genetic variants and prostate cancer survival.

CONCLUSIONS:

Common genetic variants with large impact on prostate cancer survival were not observed in this study.

IMPACT:

Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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ID Code: 94530
Item Type: Journal Article
Refereed: Yes
DOI: 10.1158/1055-9965.EPI-15-0543
ISSN: 1538-7755
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 07 Apr 2016 02:55
Last Modified: 02 Aug 2016 21:28

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