Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives

Islam, Farhadul, Gopalan, Vinod, Wahab, Riajul, Smith, Robert A., & Lam, Alfred K.-Y. (2015) Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives. Critical Reviews in Oncology/Hematology, 96(1), pp. 9-19.

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Abstract

Cancer stem cells (CSCs) are a vital subpopulation of cells to target for the treatment of cancers. In oesophageal squamous cell carcinoma (ESCC), there are several markers such as CD44, ALDH, Pygo2, MAML1, Twist1, Musashi1, Side population (SP), CD271 and CD90 that have been proposed to identify the cancer stem cells in individual cancer masses. It has also been demonstrated that stem cell markers like ALDH1, HIWI, Oct3/4, ABCG2, SOX2, SALL4, BMI-1, NANOG, CD133 and podoplanin are associated with patient's prognosis, pathological stages, cancer recurrence and therapy resistance. Finding new cancer stem cell targets or designing drugs to manipulate the known molecular targets in CSCs could be useful for improvements in clinical outcomes of the disease. To conclude, data suggest that CSCs in oesophageal squamous cell carcinoma are related to resistance to therapy and poor prognosis of patients with ESCC. Therefore, innovative insights into CSC biology and CSC-targeted therapies will help to achieve more effective management of patients with oesophageal squamous cell carcinoma.

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ID Code: 94537
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: CSC biology, CSC markers, Cancer stem cell, Oesophageal squamous cell carcinoma
DOI: 10.1016/j.critrevonc.2015.04.007
ISSN: 1040-8428
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Elsevier Ireland Ltd.
Deposited On: 07 Apr 2016 03:56
Last Modified: 07 Apr 2016 22:20

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