Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells

Mamoori, Afraa, Gopalan, Vinod, Smith, Robert Anthony, & Lam, Alfred King-Yin (2016) Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells. Biology of the Cell, 108(3), pp. 51-64.

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There are emerging data to suggest that microRNAs (miRNAs) have significant roles in regulating the function of normal cells and cancer stem cells (CSCs). This review aims to analyse the roles of miRNAs in the regulation of colon CSCs through their interaction with various signalling pathways. Studies showed a large number of miRNAs that are reported to be deregulated in colon CSCs. However, few of the studies available were able to outline the function of miRNAs in colon CSCs and uncover their signalling pathways. From those miRNAs, which are better described, miR-21 followed by miR-34, miR-200 and miR-215 are the most reported miRNAs to have roles in colon CSC regulation. In particular, miRNAs have been reported to regulate the stemness features of colon CSCs mainly via Wnt/B-catenin and Notch signalling pathways. Additionally, miRNAs have been reported to act on processes involving CSCs through cell cycle regulation genes and epithelial-mesenchymal transition. The relative paucity of data available on the significance of miRNAs in CSCs means that new studies will be of great importance to determine their roles and to identify the signalling pathways through which they operate. Such studies may in future guide further research to target these genes for more effective cancer treatment. miRNAs were shown to regulate the function of cancer stem cells in large bowel cancer by targeting a few key signalling pathways in cells.

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6 citations in Scopus
5 citations in Web of Science®
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ID Code: 94539
Item Type: Journal Article
Refereed: Yes
Keywords: Cancer Stem Cells, Colon Cancer, miRNA
DOI: 10.1111/boc.201500062
ISSN: 0248-4900
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2016 Société Française des Microscopies and Société de Biologie Cellulaire de France
Deposited On: 07 Apr 2016 04:22
Last Modified: 27 Jun 2017 13:01

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