Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance

Ebrahimi, Faeza, Gopalan, Vinod, Wahab, Riajul, Lu, Cu-Tai, Smith, Robert Anthony, & Lam, Alfred King-Yin (2015) Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance. Experimental Cell Research, 339(2), pp. 333-341.

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Abstract

In this study, we investigated the expression profiles and clinicopathological significance of miR-126 in large cohort of patients with colorectal cancers as well the cellular repercussions of miR-126 in colon cancer cells along with its targets in-vitro. Down regulation of miR-126 expression was associated with histological subtypes, peri-neural tumour infiltration, microsatellite instability and pathological staging of colorectal cancers (p<0.05). Low miR-126 expression was also associated with poorer survival in patients with colorectal cancer. Analysis of matched tissues from the same patient revealed that approximately 70% of the tested patients had similar levels of expression of miR-126 in primary cancer and cancer metastases in both lymph node and distant metastases. In addition, induced overexpression of miR-126 showed reduced cell proliferation, increased apoptosis and decreased accumulation of cells in the G0-G1 phase of the colon cancer cells. Furthermore, SW480(+miR-126) cells showed reduced BCL-2 and increased P53 protein expression. To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer.

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ID Code: 94541
Item Type: Journal Article
Refereed: Yes
Keywords: MiR-126; Colorectal cancer; Down regulation; Metastasis; Apoptosis
DOI: 10.1016/j.yexcr.2015.10.004
ISSN: 0014-4827
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Elsevier Inc.
Deposited On: 07 Apr 2016 05:52
Last Modified: 07 Apr 2016 22:27

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