Reconstruction of the ocular surface using biomaterial templates

Chirila, Traian, Suzuki, Shuko, Hirst, Lawrence, & Harkin, Damien G. (2016) Reconstruction of the ocular surface using biomaterial templates. In Chirila, Traian & Harkin, Damien G. (Eds.) Biomaterials and Regenerative Medicine in Ophthalmology [2nd edition]. Woodhead Publishing, Sawston, Cambridge, pp. 179-218.

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Abstract

This chapter discusses the effect on vision of a large group of pathological conditions, known as ocular surface disorders (OSDs), and presents the therapeutic strategies to reconstruct the abnormal ocular surface. If left untreated, most of the OSDs will lead to partial or total loss of eyesight, especially when limbal stem cell deficiency is involved. An overview of various treatment strategies is presented, with the emphasis on the development of the ex vivo expansion of corneal limbal epithelial cells (presumed to be progenitor or stem cells) and the creation of transplantable epithelial constructs. The use of naturally derived biomaterials (collagen, fibrin, amnion, etc.) or synthetic polymers (polylactides, thermoresponsive polymers, etc.) as substrata in these constructs is critically analyzed. Emphasis is placed on the templates from silk proteins, which are being developed by the authors.

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ID Code: 94551
Item Type: Book Chapter
Additional URLs:
Keywords: Corneal limbal epithelial cells, Epithelial constructs, Naturally derived biomaterial templates, Ocular surface disorders, Synthetic biomaterial templates
DOI: 10.1016/B978-0-08-100147-9.00008-0
ISBN: 9780081001479
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Deposited On: 07 Apr 2016 04:21
Last Modified: 24 Aug 2016 23:07

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