Impeding the adaptive response of prostate cancer to androgen targeted therapies with relaxin receptor antagonist

Tevz, Gregor, Hossain, Akther, Bock, Nathalie, Jeet, Varinder, Bathgate, Ross A., Williams, Elizabeth D., Lehman, Melanie, Hutmacher, Dietmar, Wade, John D., & Nelson, Colleen (2015) Impeding the adaptive response of prostate cancer to androgen targeted therapies with relaxin receptor antagonist. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.

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Abstract

Androgen deprivation and androgen targeted therapies (ATT) are established treatments for prostate cancer (PCa). Although initially effective, ATT induces an adaptive response that leads to treatment resistance. Increased expression of relaxin-2 (RLN2) is an important alteration in the adaptive response. RLN2 has a well described role in PCa cell proliferation, adhesion and tumour growth. The objectives of this study were to develop cell models for studies of RLN2 signalling and to implement in vitro assays for evaluating the therapeutic properties of the unique RLN2 receptor (RXFP1) antagonist

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ID Code: 94796
Item Type: Conference Item (Other)
Refereed: Yes
Keywords: Adaptive response, prostate cancer, androgen-targeted therapies, relaxin, receptor antagonist
ISSN: 1464-410X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Molecular Targets (111207)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2015 The Authors
Deposited On: 12 Apr 2016 23:51
Last Modified: 12 Apr 2016 23:51

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