A multiple nucleotide length polymorphism (MNLP) mediates androgen regulation of IRX4 in prostate cancer
Panchadsaram, Janatththani, Tevz, Gregor, Stylianou, Nataly, Hollier, Brett G., & Nelson, Colleen (2015) A multiple nucleotide length polymorphism (MNLP) mediates androgen regulation of IRX4 in prostate cancer. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.
Androgens and the androgen receptor (AR) play a crucial role in the initiation and progression of prostate cancer (PCa), regulating the expression of many PCa risk-associated genes. Iroquois Homeobox 4 (IRX4) has been recently identified with PCa risk and overexpressed in PCa. We observed a down-regulation of IRX4 expression in the cells undergoing epithelial to mesenchymal transition, suggesting its potential role in PCa progression and aim to delineate the androgenmediated regulation of IRX4 in PCa.
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|Item Type:||Conference Item (Other)|
|Keywords:||Multiple nucleotide length polymorphism, MNLP, androgen regulation, IRX4, prostate cancer|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||2015 The Authors|
|Deposited On:||13 Apr 2016 00:26|
|Last Modified:||13 Apr 2016 00:26|
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