Extracellular vesicles mediate paracrine signalling in androgen deprived prostate cancer
Soekmadji, Carolina, Ruelcke, Jayde E., Wang, Chenwei, Riches, James D., McPherson, Stephen, Russell, Pamela, Hill, Michelle M., Jenster, Guido W., & Nelson, Colleen (2015) Extracellular vesicles mediate paracrine signalling in androgen deprived prostate cancer. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.
The androgen receptor (AR) is the main therapeutic target for advanced prostate cancer (PCa). Current treatments have focused on inhibiting the transcriptional activity of the AR, however androgens can also induce non-genomic effects by facilitating the initiation of kinase signaling cascades in PCa. Cells, including PCa, secrete extracellular vesicles (EV), which are able to mediate communication between cells and can also contribute towards these processes.
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|Item Type:||Conference Item (Other)|
|Keywords:||biomarkers, extracellular vesicles, paracrine signalling, androgen deprived prostate cancer|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Molecular Targets (111207)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||2015 The Authors|
|Deposited On:||13 Apr 2016 00:48|
|Last Modified:||13 Apr 2016 00:48|
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