Kallikrein-related peptidase 4 induces tumour microenvironment alterations that support tumour growth

Fuhrman-Luck, Ruth Anna, Kryza, Thomas, Hastie, Marcus Lachlan, Stoll, Thomas, Kleifeld, Oded, Ho, Bosco, Lehman, Melanie, Rockstroh, Anja, Nelson, Colleen, Gorman, Jeffrey John, Loessner, Daniela, & Clements, Judith (2015) Kallikrein-related peptidase 4 induces tumour microenvironment alterations that support tumour growth. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.

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Abstract

Kallikrein-related peptidase 4 (KLK4) is a protease with elevated production in prostate cancer versus benign tissue. KLK4 expression is associated with prostate cancer risk, and its activity favours tumour progression through increasing cell motility and growth. Importantly, over-production of KLK4 in prostate glandular cells precedes tumour formation, positioning the enzyme to play a role in early remodelling of the tumour microenvironment, a process essential for tumour growth. We sought to identify the proteins and downstream signalling pathways targeted by KLK4 activity, to define its role in tumour microenvironment remodelling and evaluate the efficacy of KLK4 inhibition as a cancer therapy.

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ID Code: 94802
Item Type: Conference Item (Other)
Refereed: Yes
Keywords: Kalikreins, Kalikrein-related peptidase, tumour microenvironment, tumour growth, prostate cancer
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2015 The Authors
Deposited On: 13 Apr 2016 01:02
Last Modified: 13 Apr 2016 01:02

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