A 3D in vitro model reflecting the androgen deprivation state in prostate cancer bone metastasis

Bock, Nathalie, Loessner, Daniela, Hutmacher, Dietmar, & Clements, Judith (2015) A 3D in vitro model reflecting the androgen deprivation state in prostate cancer bone metastasis. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.

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Abstract

In castrate-resistant prostate cancer (CRPC), the prevailing organ for metastasis is bone, where the survival of cancer cells is regulated by the permissive metastatic niche offered by the bone marrow. The tumour microenvironment and cellular interactions with the matrix and bone cells enable metastasis and lead to cancer cells becoming androgen resistant. Hence, 3D models that mimic CRPC in terms of an androgen deprivation state (ADS) are needed to identify the mechanisms for CPRC growth in bone and further develop therapeutic strategies.

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ID Code: 94804
Item Type: Conference Item (Other)
Refereed: Yes
Keywords: prostate cancer, bone metastasis, 3D in vitro model, androgen deprivation
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: 2015 The Authors
Deposited On: 13 Apr 2016 01:08
Last Modified: 13 Apr 2016 01:08

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