Investigating the role of neuroendocrine transdifferentiation in the progression to castration resistant prostate cancer

Rather, Ellca, Sweeney, Katrina, Stylianou, Nataly, Nelson, Colleen, Williams, Elizabeth D., & Hollier, Brett G. (2015) Investigating the role of neuroendocrine transdifferentiation in the progression to castration resistant prostate cancer. In 2nd Prostate Cancer World Congress, 17-21 August 2015, Cairns Convention Centre, Cairns, Qld.

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Abstract

Androgen targeted therapies (ATT) are the most commonly used treatments in prostate cancer (PCa).While these therapies are initially effective, PCa cells are able to activate adaptive response pathways to survive these therapies and progress to castration resistant PCa (CRPC), a highly aggressive and ultimately lethal stage of the disease. Neuroendocrine transdifferentiation (NEtD), a process whereby PCa cells gain neuroendocrinelike characteristics, has been implicated in the development of CRPC. The objective of this study is to develop and characterise models of therapy-induced NEtD to investigate the role of this adaptive plasticity in the progression to CRPC.

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ID Code: 94826
Item Type: Conference Item (Other)
Refereed: Yes
Keywords: neuroendocrine, trans-differentiation, prostate cancer, cancer progression, castration resistant prostate cancer
ISSN: 1464-4096
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 14 Apr 2016 01:36
Last Modified: 17 Apr 2016 04:04

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